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Kexing launched the world's first phase III clinical study of bivalent inactivated enterovirus vaccine. On December 13th, the first volunteer was enrolled in the phase III clinical study of bivalent inactivated enterovirus vaccine developed by Beijing Kexing Biological Products Co., Ltd., a subsidiary of Kexing Holding Biotechnology Co., Ltd. (hereinafter referred to as "Kexing"). The vaccine is used to prevent hand, foot and mouth disease caused by enterovirus 71 (EV71) and coxsackie virus 16 (CA16). A multicenter, randomized, double-blind, controlled study design was adopted in this phase III clinical study to evaluate the protective efficacy, safety and immunogenicity of the vaccine in children aged 6-71 months.Nearly 30 listed companies announced after-hours that their products would be selected, and the tenth batch of centralized drug procurement (centralized drug procurement) organized by the state was opened in Shanghai yesterday. According to incomplete statistics, as of press time, it includes Fuyuan Pharmaceutical, Yifan Pharmaceutical, ST Tiansheng, Hokuriku Pharmaceutical, Haizheng Pharmaceutical, Zhongheng Group, Yuandong Bio, Kelun Pharmaceutical, China Resources Shuanghe, Sinopharm Modern, Lingkang Pharmaceutical, Xuantai Pharmaceutical, Jiuzhou Pharmaceutical, Kang Enbei, Laimei Pharmaceutical, Kanghong Pharmaceutical, Huasen Pharmaceutical, Borui Pharmaceutical, Xianzeng Pharmaceutical. Among them, Kelun Pharmaceutical announced that 12 kinds of drugs, such as sodium acetate Ringer injection, sodium bicarbonate Ringer injection and gliclazide tablets, were to be selected.The self-built valuation model of bank wealth managers has met with "standardization": some institutions have re-adopted the strategy of excess return of the bank's tier-2 capital bonds with the valuation system of China Securities and China Securities, and recently, the regulatory authorities issued a document to the bank wealth management subsidiary, demanding that the self-built valuation model should not be used to smooth the net value fluctuation, and the valuation standards provided by third parties such as China Securities and China Securities should be adopted, and self-inspection and rectification should be carried out. The purpose of this move is to prevent the bank's wealth management subsidiaries from adjusting product income through self-built models, and to carry out "fund pool" business in disguise to ensure market fairness. At present, a number of bank wealth management subsidiaries have received this document, and have begun to adjust the net value calculation methods of day-opening and closed wealth management products, and re-adopt third-party valuation for investment products such as bank tier 2 capital bonds. A person from a bank financing subsidiary told reporters that he heard that the financial supervision department held a small-scale meeting last week, asking the bank financing subsidiary to respect the new asset management rules and not to violate accounting standards. In addition, the relevant departments also require the financial subsidiaries of banks that have used the self-built valuation model to carry out rectification, and the financial subsidiaries that have been notified shall submit corresponding rectification plans and measures reports within one month. In the view of the above-mentioned bank wealth managers, it is not excluded that some bank wealth management subsidiaries have lowered the allocation ratio of bank tier-2 capital bonds due to the influence of regulatory policies, because when the self-built valuation model is "standardized", the strategy of over-allocating bank tier-2 capital bonds to obtain excess returns becomes increasingly difficult when the net product value fluctuates relatively smoothly. (per meridian)

Shanghai launched a new special campaign and issued coupons again! The civilized market and supporting promotion in Wujiaochang business district lasted for 10 days. On December 13th, the special action of "Going to the Covenant of Civilizations" by civilized units in Shanghai to help the joint development of cultural and sports tourism and business exhibitions was launched. The first stop was opened in Wujiaochang, Yangpu District, and it was divided into three sections: civilized market, flash stage and supporting promotion, which will last for 10 days. After mobilization and negotiation, merchants and enterprises in Wujiaochang Business Circle, Daxue Road and Guohua Plaza jointly launched a number of exclusive coupons for "Going to the Covenant of Civilization" during the event, including more than 30,000 limited coupons and 18 unlimited coupons, covering restaurants, food, beauty and clothing, and fashionable life businesses, which not only brought tangible benefits to the citizens, but also helped the business circle to drain and develop the real economy. The citizens can check the H5 activity page through the "Shanghai Yangpu" WeChat WeChat official account, and grab coupons and write them off at 10:00 every day from December 13th to 22nd. (Watch the news)Bayrou was appointed as the new Prime Minister of France. French public opinion regards him as a staunch political ally of Macron. The Elysee Palace, the French presidential palace, announced on the 13th that President Macron appointed francois bayrou, chairman of the Democratic Movement Party, as the new Prime Minister on the same day, replacing Banier, who resigned after being impeached by the National Assembly. According to French media reports, Macron had a telephone conversation with Bayrou on the evening of 12th, and on the morning of 13th, Macron met Bayrou in the presidential palace and talked again. Macron subsequently announced the appointment decision. Bayrou became the fourth French prime minister this year. Beru founded the Democratic Movement Party, a centrist party, in 2007, and has served as its chairman ever since. In 2017, Bayrou announced that he would give up running for the French president, and formed an alliance with Macron, one of the popular candidates in the presidential election at that time and the chairman of the "Forward" movement, to fully support Macron's presidential election. In 2022, in the process of Macron's re-election, Bayrou led the Democratic Movement Party to continue to form an alliance with the ruling party. French public opinion regards Bayrou as a staunch political ally of Macron. (Xinhua News Agency)As a result of providing loans with private fund property, Haisi Quanzong's private placement and responsible person were supervised to issue a warning letter. On December 13th, Qingdao Securities Regulatory Bureau issued a notice saying that after investigation, Qingdao Haisi Quanzong Private Fund Management Co., Ltd. (hereinafter referred to as "Haisi Quanzong Private Placement") provided loans with private fund property, which violated the regulations. Song Xiuhong was then the legal representative and chairman of Haisi Quanzong Private Equity, and Liu Jialiang is now the legal representative and chairman of Haisi Quanzong Private Equity. Since the establishment of Haisi Quanzong Private Equity, Wang Zhaohui has been the general manager. During his tenure, he failed to fulfill his duties and strictly abide by laws and regulations, and was responsible for the above acts. Qingdao Securities Regulatory Bureau took administrative supervision measures to issue warning letters to Haisi Quanzong Private Equity, Song Xiuhong, Liu Jialiang and Wang Chaohui.

Macron rejected our proposal and appointed one of his allies as Prime Minister. We will not enter the government, and Macron chooses to continue his policy.Huawang Technology: Zhang Yancheng, the director, plans to reduce the company's shares by no more than 0.3443%. Huawang Technology announced that Zhang Yancheng, the company's director and senior manager, plans to reduce the company's shares by no more than 1.6 million shares through centralized bidding on the Shanghai Stock Exchange within three months after the announcement date, accounting for 0.3443% of the company's total share capital. The reduction price will be determined according to the market price. Zhang Yancheng currently holds 6,671,700 shares of the company, accounting for 1.4357% of the company's total share capital.General Administration of Market Supervision: Efforts should be made to optimize the consumption environment and promote large-scale equipment renewal and trade-in of consumer goods by standards. The party group of General Administration of Market Supervision held an enlarged meeting to convey the spirit of studying the Central Economic Work Conference. The meeting demanded that the construction of a unified national market should be accelerated, fair competition governance should be strengthened, and the economic cycle should be promoted smoothly. Efforts should be made to optimize the consumption environment, promote large-scale equipment renewal and trade-in of consumer goods with standards, and help expand domestic demand. It is necessary to give full play to the supporting role of quality infrastructure and boost scientific and technological innovation and the development of new quality productive forces. Efforts should be made to standardize the market order and promote mutual benefit and win-win for all parties in the platform economy. It is necessary to constantly optimize the ways and means of market supervision, improve the efficiency of supervision, and stabilize market expectations. It is necessary to effectively improve the safety supervision ability of food, medicine, industrial products and special equipment, and timely prevent and resolve major risks. It is necessary to improve the working mechanism for implementing the decision-making and deployment of the CPC Central Committee and strengthen the comprehensive and strict management of the party's political responsibility. It is necessary to do a good job in safe production in the field of market supervision at the end of the year and at the beginning of the year, and stabilize the price and quality of important people's livelihood commodities.